

Check the Character sheet for more information on all of them. Fortune, Painwheel, Valentine, and Double. The default cast of playable characters includes Filia, Cerebella, Peacock, Parasoul, Ms. The game also features a special combo detection system: if a player begins an infinite combo, the damage strikes change color, and the game will allow the opponent to "burst" out of the infinite and knock the offensive player away.

It features a "ratio system" that allows each player to choose to fight with one character or a team of up to three characters, resulting in different combinations for a particular match. Skullgirls' gameplay carries the feel of old-school arcade fighters while providing a high-definition twist. The result is an eclectic and delightfully quirky cast and setting. Skullgirls features work from an all-star development crew: fighting game veteran Mike "Mike Z" Zaimont (he of REAL SOVIET DAMAGE fame) led the project, Cristina Valenzuela directed the voice acting, Alex Ahad (whose prior work credits include Lava Punch, Studio UDON's Tribute books, and promotional art for Scott Pilgrim) created artwork for the game, and Michiru Yamane provided the music. The game is currently in the hands of three teams: Autumn Games continues to act as the publisher, while active development is handled by Future Club, a studio formed by some of Lab Zero's former developers, and Hidden Variable Studios, who both work on the main game and act as the primary dev team for the mobile version. It was maintained by Lab Zero Games until its closure in 2020. The game was developed by Reverge Labs, published by Autumn Games and formerly Konami as well as by Arc System Works in Japan. (The look and the name both derive from Batman: The Animated Series.) The game combines Animesque character designs with a stylized Golden Age film motif, employing "Dark Deco" stage backgrounds and a cinematic presentation.

Skullgirls is a frenetic 2D Fighting Game putting players in control of an (almost) all-female cast à la Arcana Heart.
